Tag: nootropics

Tianeptine is a Nutritional Supplement That Might Need Restrictions

What is tianeptine?

Discovered and patented by the French Society of Medical Research in the 1960s, Tianeptine is available in a number of European, Asian, and Latin American countries. But the drug that is used primarily in the treatment of clinical depression is not prescribed in Canada, the U.K., the U.S., Australia, and New Zealand. One of the reasons for its limited availability is, once again, that Tianeptine does not fit neatly into any known class of antidepressants. In fact, it was mislabeled as an selective serotonin reuptake enhancer (SSRE) until only recently. We also know that tianeptine has disparate chemical and pharmacological properties that have left researchers scratching their proverbial heads as to how the drug produces its antidepressant effects. One thing we know for certain, however, is that tianeptine works, and works well!

How well it works

As the most widely used tricyclic (TCA) antidepressant, amitriptyline is on the World Health Organization’s List of Essential Medicines. Approved for use in 1961, it has been a benchmark for all other drugs in its class ever since. In fact, many researchers believe that amitriptyline may have superior efficacy than many, even most, SSRIs and SNRIs in treating major depressive episodes. It is surprising then that tianeptine compares favorably to the popular pill in many key areas.

Researchers may not know how it works, but tianeptine’s efficacy against major depression has never been in doubt. Compared to amitriptyline, imipramine, maprotiline, and other TCAs, tianeptine has significantly fewer side effects. It even stacks up well against fluoxetine (a.k.a. Prozac), the most widely prescribed SSRI.

One advantage tianeptine has over most other antidepressants is its remarkable anxiolytic properties. This is important because anxiety is one of the most common symptoms of clinical depression. As result, tianeptine has proven effective at treating a wide spectrum of anxiety disorders that are often involved in major depressive episodes, including panic and post-traumatic stress disorders.

Tianeptine may also have a beneficial effect on cognition, due in part to its relative lack of sedative qualities. According to numerous studies, drowsiness was a fairly uncommon side effect of the medication. Tianeptine has also compared favorably to other antidepressants in tolerability tests, where subjects consistently reported fewer and less intense adverse effects of sustained treatment.

Medical benefits

There are several reasons why tianeptine is not considered a first-line antidepressant. To begin with, it belongs to an older class of drugs (TCAs) that generally have a higher risk toxicity in overdose and lower tolerability than newer medications in SSRI and SNRI drug classes. Secondly, it is not sold in many countries. It is this last fact that is particularly puzzling, since many clearly inferior drugs in its class are widely available. As we mentioned earlier, tianeptine have proven every bit as efficacious against major depressive episodes as amitriptyline (the most popular tricyclic antidepressant), but with significantly fewer side effects. The drug even has advantages over SSRIs and SNRIs, for which hundreds of millions of prescriptions are dispensed each year in America. Such as?

As popular as they may be, it is well established that serotonin enhancers (SSRIs and SNRIs) cause problems in the bedroom. Diminished libido, delayed sexual arousal, and muted or absent orgasm are common symptoms of these prescription medications. Because it does not affect serotonin levels directly, taking tianeptine will not cause adverse sexual side effects. In fact, there is some evidence that sexual function could actually be enhanced by the combination of non-stimulating mood brightener and non-sedative anti-anxiety agents. Why then is tianeptine so much harder to find?

Contrary to rumors on the internet, there is no conspiracy that has kept the drug from those in need, wherever they might reside. The real reason tianeptine is not sold in some countries is because the companies that manufacture it have decided not to enter certain markets, mostly likely because the costs of entry is prohibitive. With that said, there are many in the psychiatric community that believe the time-tested psychotropic drug could help millions were it more widely available.

Who should take it?

Because it does not cause sedation or sleeping problems, tianeptine is suitable for patients who are sensitive to the unwanted effects of most antidepressants, including the elderly and those recovering from alcohol withdraw. The drug could also be of great benefit to those who suffer from anxiety disorders. How?

At last count, forty million American adults struggled with some form of anxiety on a regular basis. About one-third of those that seek treatment also report regular bouts of depression, since the two disorders are highly correlated with each other. In other words, those who are depressed are often anxious and vice versa. And since tianeptine is both a antidepressant and an anxiolytic, it can be used to treat both illnesses simultaneously.

Why it works

Although recent discoveries have provided some much-needed insight, researchers have merely scratched the surface when it comes to the complicated series of chemical reactions tianeptine intake triggers in the brain. At its simplest level, we know that unchecked stress causes the adrenal glands to secrete a surfeit of cortisol, a powerful stress hormone. The primary function of this steroid is to increase blood sugar and give the body the energy and strength it needs to defend itself from danger. Also known as the fight-or-flight response or the stress reaction, this involuntary process tends to lower mood levels in order to help us focus on the task at hand. But when cortisol and other stress hormones remain at elevated levels for protracted periods of time, they can cause clinical depression. In fact, cortisol levels are now used as a biological marker for suicide risk.

Current evidence strongly suggests that tianeptine works to prevent and even reverse the neural damage that is caused by stress or stress hormones like cortisol. Researchers also believe that continued use of the drug may help normalize the hypothalamic-pituitary-adrenal (HPA) system, which is responsible for monitoring and releasing cortisol and other stress hormones. In other words, tianeptine may help at-risk individuals deal with stressful environments and situations a bit better by normalizing their HPA system.

Conclusion

As with many psychotropic medications, tianeptine won’t work for everyone: research shows that perhaps as much as one-third of users do not respond as expected. With that said, tianeptine has proven efficacious in antidepressant cocktails when monotherapy, or use of a single first-line drug, has failed. Most promising of all is the drug’s apparent ability to protect against and even reverse the effects of hypercortisolemia – a condition that results from prolonged exposure to excessive cortisol levels, and one that is strongly linked to major depressive episodes. Long-term use of tianeptine may therefore protect against relapse and recurrence of clinical depression.

At the end of the day, depressive illness is an incredibly complex disorder that we may never fully understand. What we do know, however, is that the more tools we have to fight melancholia, the more hope we can offer those who suffer its devastating effects. Tianeptine may not be the catholicon its supporters suggest, but what it has to offer is both valuable and unique. An established mood-brightener-cum-anti-anxiety medication that is well tolerated and relatively safe, tianeptine’s neglect by the Anglo-American psychiatric community is shortsighted and undeserved.

A Few Nootropics to Help with Video Editing

Video editing can be a tedious but rewarding task. For those who have made it a profession, it can be mostly rewarding when you are editing your own material you are passionate about and tedious when it is someone else’s work. Even though there are plenty of ways to improve the quality of your work through practice and tutorials, there are chemical compounds that can make a big difference in your brain power as well.

Every time you use a nootropic drug you’ll find a variety of different benefits and side effects, which is why it is important to maintain the right mindset when you are continuing through this process of self-education and mastery. As you’ll realize, there are plenty of ways for you to improve the quality of your cognition.

This article is going to help you to find the nootropics you need to accelerate your career in the world of video editing. As you’ll notice, there are plenty of specifics to this field that can make a big difference in how you are challenged.

Racetams – there are a number of different racetam drugs that you can use in order to improve brain function, but it is even more important for video editors. With this creative work, it is nice to have a way of changing the connections in your brain to make things click on a different level. For the same reason psychedelics are so useful, it is helpful for you to have smaller versions of that through racetams like piracetam and aniracetam.

In the past when I have taken aniracetam, it has made a big difference in my ability to see visual cues and colors. A lot of the time this helped me when I was doing things like jiu-jitsu, but it also helped me to improve the way that I was working as well. It is a stimulant in some regard and that makes a big difference when trying to do work, but without feeling all hopped up on caffeine!

Bulletproof coffee – sometimes being all hopped up on caffeine isn’t the worst thing in the world! There are times where it is nice to have a caffeine boost and the combination of butter, coconut oil (or MCT oil) and coffee makes a big difference. If you are consuming these together, there is a good chance you can improve the quality of your cognitive performance and work for longer hours at a time.

Most of the time, people who are using butter coffee find that it is a great way of enjoying coffee, getting replacement calories so they don’t have to eat, and getting a cognitive boost. This is a win-win-win!

Unique blends – there are also unique blends that you can utilize in order to improve the quality of your cognitive performance. Some people stick to Alpha Brain because it is the most popular. There are many well-written Alpha Brain reviews that you can find online, but it is up to you to take everything with a grain of salt as they are trying to sell you something undoubtedly! Keep this in mind whenever you read a review online.

Overall, there are so many different ways that you can improve the quality of your brain, but it is important for you to have the right kind of mentality when you are trying to do things. The vast majority of people who are finding nootropics aren’t interested in following all the latest and greatest information either. If you are video editing, you are more than likely trying to enhance the quality of your work. Any video editor can appreciate better work.

Fasting is the Best Nutritional Supplement

When it comes to improving your life in general terms, you have to do a full analysis and calculation. You may find that some drugs really improve your concentration, but they come with a huge crash and a lot of side effects. Other drugs don’t do much, but they don’t have any side effects either. The best value for your time and energy is a compilation of many different factors and one of those is fasting.

The fasting nutritional supplement is not actually a nutritional supplement at all! It’s just a practice that you can use in order to get a much better experience from your life. Here are a few of the reasons why:

  1. Anti-aging – it is proven that reducing caloric intake has a huge impact on aging. People (and mammals in general) that eat during a smaller period or eat fewer calories will have a much longer lifespan. There is much evidence to suggest that aging is a factor that fasting can negate almost completely. Some studies show a 24% increase in lifespan with fasting (caloric restriction) alone.
  2. Mental performance – after your brain gets used to not using glucose as fuel constantly, it becomes much easier to maintain high mental performance. The vast majority of people who are using markers like mental performance to get ahead at work can find many advantages from this type of thing if they are focusing on the right effects.

Of course, there are plenty of other benefits that you can use to your advantage as well. The vast majority of people who are using the practice find that it is even better when combined with smart drugs and nootropics. One anti-anxiety smart drug called ashwagandha makes a big difference and has a number of profound effects. Even fasting is useful when you have something like adrafinil as the food will not interact negatively with the psychoactive ingredients.

Every Time You Choose This Smart Drug You Get Smarter

There are few nootropic drugs that have the same kind of impact as modafinil (also known as provigil). Even though people find out that the drug is hard to get or it only improves concentration and focus, they also learn that there are plenty of benefits outside of this. Modafinil is a smart drug that isn’t just about getting more focused, but also about improving the quality of that focus and building intelligence over time.

What this looks like in practice is that you can improve your intelligence while studying or doing some kind of work while on the drug. The following article will explain all.

Improving Nootropics Usage

Most people who take this nootropic compound are going to find that it has a number of benefits for studying in the moment. According to the Yerkes-Dodson law, it doesn’t actually make smart people smarter in the moment. However, it can add to general cognition, which has the effect over a course of time. People consistently have to deal with the issue and it is something that nobody likes.

Modafinil allows people to study for a lot longer and a lot more efficiently so that even if they are not going to perform as well on an exam, they can still get the information locked into their head in order to have the best experience. This is one of the best experiences that you can have when it comes to improving your learning ability.

Most people do not consider modafinil for learning enhancement because they are so stuck on whether or not they can improve the level of their memory with such a drug that helps with focus and attention. The vast majority of people who are using these kinds of nootropics figure out that there are other alternatives to modafinil, however. People that don’t want to go against the law find that the adrafinil smart drug called nuvigil is a great option for improving your general cognitive abilities.