Tianeptine is a Nutritional Supplement That Might Need Restrictions

What is tianeptine?

Discovered and patented by the French Society of Medical Research in the 1960s, Tianeptine is available in a number of European, Asian, and Latin American countries. But the drug that is used primarily in the treatment of clinical depression is not prescribed in Canada, the U.K., the U.S., Australia, and New Zealand. One of the reasons for its limited availability is, once again, that Tianeptine does not fit neatly into any known class of antidepressants. In fact, it was mislabeled as an selective serotonin reuptake enhancer (SSRE) until only recently. We also know that tianeptine has disparate chemical and pharmacological properties that have left researchers scratching their proverbial heads as to how the drug produces its antidepressant effects. One thing we know for certain, however, is that tianeptine works, and works well!

How well it works

As the most widely used tricyclic (TCA) antidepressant, amitriptyline is on the World Health Organization’s List of Essential Medicines. Approved for use in 1961, it has been a benchmark for all other drugs in its class ever since. In fact, many researchers believe that amitriptyline may have superior efficacy than many, even most, SSRIs and SNRIs in treating major depressive episodes. It is surprising then that tianeptine compares favorably to the popular pill in many key areas.

Researchers may not know how it works, but tianeptine’s efficacy against major depression has never been in doubt. Compared to amitriptyline, imipramine, maprotiline, and other TCAs, tianeptine has significantly fewer side effects. It even stacks up well against fluoxetine (a.k.a. Prozac), the most widely prescribed SSRI.

One advantage tianeptine has over most other antidepressants is its remarkable anxiolytic properties. This is important because anxiety is one of the most common symptoms of clinical depression. As result, tianeptine has proven effective at treating a wide spectrum of anxiety disorders that are often involved in major depressive episodes, including panic and post-traumatic stress disorders.

Tianeptine may also have a beneficial effect on cognition, due in part to its relative lack of sedative qualities. According to numerous studies, drowsiness was a fairly uncommon side effect of the medication. Tianeptine has also compared favorably to other antidepressants in tolerability tests, where subjects consistently reported fewer and less intense adverse effects of sustained treatment.

Medical benefits

There are several reasons why tianeptine is not considered a first-line antidepressant. To begin with, it belongs to an older class of drugs (TCAs) that generally have a higher risk toxicity in overdose and lower tolerability than newer medications in SSRI and SNRI drug classes. Secondly, it is not sold in many countries. It is this last fact that is particularly puzzling, since many clearly inferior drugs in its class are widely available. As we mentioned earlier, tianeptine have proven every bit as efficacious against major depressive episodes as amitriptyline (the most popular tricyclic antidepressant), but with significantly fewer side effects. The drug even has advantages over SSRIs and SNRIs, for which hundreds of millions of prescriptions are dispensed each year in America. Such as?

As popular as they may be, it is well established that serotonin enhancers (SSRIs and SNRIs) cause problems in the bedroom. Diminished libido, delayed sexual arousal, and muted or absent orgasm are common symptoms of these prescription medications. Because it does not affect serotonin levels directly, taking tianeptine will not cause adverse sexual side effects. In fact, there is some evidence that sexual function could actually be enhanced by the combination of non-stimulating mood brightener and non-sedative anti-anxiety agents. Why then is tianeptine so much harder to find?

Contrary to rumors on the internet, there is no conspiracy that has kept the drug from those in need, wherever they might reside. The real reason tianeptine is not sold in some countries is because the companies that manufacture it have decided not to enter certain markets, mostly likely because the costs of entry is prohibitive. With that said, there are many in the psychiatric community that believe the time-tested psychotropic drug could help millions were it more widely available.

Who should take it?

Because it does not cause sedation or sleeping problems, tianeptine is suitable for patients who are sensitive to the unwanted effects of most antidepressants, including the elderly and those recovering from alcohol withdraw. The drug could also be of great benefit to those who suffer from anxiety disorders. How?

At last count, forty million American adults struggled with some form of anxiety on a regular basis. About one-third of those that seek treatment also report regular bouts of depression, since the two disorders are highly correlated with each other. In other words, those who are depressed are often anxious and vice versa. And since tianeptine is both a antidepressant and an anxiolytic, it can be used to treat both illnesses simultaneously.

Why it works

Although recent discoveries have provided some much-needed insight, researchers have merely scratched the surface when it comes to the complicated series of chemical reactions tianeptine intake triggers in the brain. At its simplest level, we know that unchecked stress causes the adrenal glands to secrete a surfeit of cortisol, a powerful stress hormone. The primary function of this steroid is to increase blood sugar and give the body the energy and strength it needs to defend itself from danger. Also known as the fight-or-flight response or the stress reaction, this involuntary process tends to lower mood levels in order to help us focus on the task at hand. But when cortisol and other stress hormones remain at elevated levels for protracted periods of time, they can cause clinical depression. In fact, cortisol levels are now used as a biological marker for suicide risk.

Current evidence strongly suggests that tianeptine works to prevent and even reverse the neural damage that is caused by stress or stress hormones like cortisol. Researchers also believe that continued use of the drug may help normalize the hypothalamic-pituitary-adrenal (HPA) system, which is responsible for monitoring and releasing cortisol and other stress hormones. In other words, tianeptine may help at-risk individuals deal with stressful environments and situations a bit better by normalizing their HPA system.


As with many psychotropic medications, tianeptine won’t work for everyone: research shows that perhaps as much as one-third of users do not respond as expected. With that said, tianeptine has proven efficacious in antidepressant cocktails when monotherapy, or use of a single first-line drug, has failed. Most promising of all is the drug’s apparent ability to protect against and even reverse the effects of hypercortisolemia – a condition that results from prolonged exposure to excessive cortisol levels, and one that is strongly linked to major depressive episodes. Long-term use of tianeptine may therefore protect against relapse and recurrence of clinical depression.

At the end of the day, depressive illness is an incredibly complex disorder that we may never fully understand. What we do know, however, is that the more tools we have to fight melancholia, the more hope we can offer those who suffer its devastating effects. Tianeptine may not be the catholicon its supporters suggest, but what it has to offer is both valuable and unique. An established mood-brightener-cum-anti-anxiety medication that is well tolerated and relatively safe, tianeptine’s neglect by the Anglo-American psychiatric community is shortsighted and undeserved.

Duromine is South Africa’s Secret

Fat loss isn’t a challenging as it might look at first. Even though there are plenty of food choices that can keep you fat and unhealthy, there are more technologies coming online that can have a really profound impact on your health and overall function. In this article, we are going to focus on the secret from South Africa that is making some big wins for many people.

As you are going to see, there are many reasons to use fat burning supplements, but there aren’t always available options. This specific South African product will help to dispel the myth that fat burners don’t work.

The Duromine Way

The thing that is so impactful for millions of South Africans is called duromine, which is a simple over-the-counter appetite suppressant that has a lot of benefits for people in both the long and the short term. Whenever you reduce your appetite and eat less, there is a good chance you are going to be able to not only lose weight, but also enhance long term health. Fasting protocols have been used for thousands of years to ensure people stay healthy even though it sounds counter-intuitive.

How does duromine compare with many of the other appetite suppressants? Well, if you compare it to caffeine it is better even though it is less popular. Many people drink caffeine anyway and the benefits aren’t that great compared to the new and novel technologies. Of course, there are disadvantages of caffeine as well, which is that it no longer works after too long!

Another similar substance is nicotine, but most people only reduce their appetite when they are smoking cigarettes, which is not at all healthy for your lungs or your body. Even if you are eating less, it isn’t worth it if you are going to have to smoke!

A Better Way to Burn Fat

Most people are looking for a better way to burn fat especially if they are reading Nutritional Supplement Info. This site is full of different ways that you can burn fat, reduce your weight, and look your best. Not only is it useful for improving the way that you look, but it is going to help you in the long run as well.

Most people who are getting rid of excess pounds in the new year aren’t looking towards technology in the right way. Instead of beating your head in the gym, enjoy a fat loss supplement.

How Important is Magnesium Really?

Every day hundreds of enzymatic actions happen without you knowing or caring about it. All of this is done as part of the basic process each human has over millions of years of evolution. One important aspect of modern science has been a better understanding of how we actually do function at a cellular and biological level. The things that we have learned as a result are incredibly important not only to reduce diseases and increase our lifespan, but also to increase the quality of life while we are on earth.

One of the biggest advances is in the micronutrient realm. Magnesium, for instance, is one of the most important nutrients that we can have in our body and most people do not have enough. If you are trying to incorporate a lot of exercise into your daily routine, the effects could be even worse! You might find that you are unable to sleep properly and have other cognitive problems, which are all signs of magnesium deficiencies of some sort.

For some people, low magnesium can cause nerve health problems. The issue most people face once they hear about the importance of magnesium is finding the right kind. There are many types of magnesium and all of them are not created equally. Here are some of the better options that you can use in order to optimize your cognitive performance.

Magnesium Glycinate – this is a highly bioavailable form of magnesium and even though it does not cross the blood-brain barrier, it is effective in all of the enzymatic actions that you need throughout the body. This has effects that are useful for the brain even if it doesn’t change the elemental levels of magnesium within the brain such as…

Magnesium L-Threonate – this type of magnesium is known to be a well-absorbed and bioavailable option for the brain, which is going to make significant improvements in your overall and brain health. If you combine these two options, you are going to have the best possible effects with better performance.

Of course, if you are trying to find the right magnesium supplement, you might want to see which blends are available and the different types. A dosage of magnesium per day is around 200 mg so if you are taking non-bioavailable options, it is a good idea for you to consider how much you will need on a daily basis!

During Christmas Don’t Fall Victim to These Traps

Christmas is one of the best times of the year and it is a time of happiness, good food, and family. When all of these combine it can be a recipe for disaster from a nutritional and aesthetic perspective. Many people work for years upon years to get the physique they are looking for and lose it all in a single season of treats and sweets. Instead of falling victim to these traps, you can find healthy and alternative options that make a big difference in the way that you approach the holidays.

The best part is, you can do all of these things without making the family made or coming across as a pompous, arrogant, ass! Here are a few of the traps that many people often fall victim to:

  1. Eating too often – you can enjoy a lot of delicious food over the holidays if you just make sure to do it within a couple of well-timed meals per year. Don’t feel miserable when you are enjoying family time and great food. Just make sure that you have two and no more than three specific instances where you eat. More than likely, it is going to make a big difference to stop eating so often during the holidays. Many people make the mistake of eating throughout the entire day and this is where the real fat gain starts to happen.brain
  2. Not taking nutritional supplements – this is a major problem that people face during the holidays because it slips their mind. If you are on a strict regimen that includes shape platinum, it isn’t a good idea to stop taking it just before the holiday season. In fact, taking shape platinum is probably more important as you go through the holiday season eating higher calories
  3. Poor exercise habits – the best habit that you can focus on is your food. They say your abs are made in the kitchen and for good reason. However, it is a lot easier to stay healthier and fit when you have good exercise habits. Doing the right amount of exercise can really have a profound impact on the way you come out of the holidays. Otherwise, you might find yourself a little heavier than you anticipated!

If you can avoid these problems, you will be in good hands. Just make sure that you are taking every precaution and consideration to make your life enjoyable while at the same time seeing the results that you like.

A Few Nootropics to Help with Video Editing

Video editing can be a tedious but rewarding task. For those who have made it a profession, it can be mostly rewarding when you are editing your own material you are passionate about and tedious when it is someone else’s work. Even though there are plenty of ways to improve the quality of your work through practice and tutorials, there are chemical compounds that can make a big difference in your brain power as well.

Every time you use a nootropic drug you’ll find a variety of different benefits and side effects, which is why it is important to maintain the right mindset when you are continuing through this process of self-education and mastery. As you’ll realize, there are plenty of ways for you to improve the quality of your cognition.

This article is going to help you to find the nootropics you need to accelerate your career in the world of video editing. As you’ll notice, there are plenty of specifics to this field that can make a big difference in how you are challenged.

Racetams – there are a number of different racetam drugs that you can use in order to improve brain function, but it is even more important for video editors. With this creative work, it is nice to have a way of changing the connections in your brain to make things click on a different level. For the same reason psychedelics are so useful, it is helpful for you to have smaller versions of that through racetams like piracetam and aniracetam.

In the past when I have taken aniracetam, it has made a big difference in my ability to see visual cues and colors. A lot of the time this helped me when I was doing things like jiu-jitsu, but it also helped me to improve the way that I was working as well. It is a stimulant in some regard and that makes a big difference when trying to do work, but without feeling all hopped up on caffeine!

Bulletproof coffee – sometimes being all hopped up on caffeine isn’t the worst thing in the world! There are times where it is nice to have a caffeine boost and the combination of butter, coconut oil (or MCT oil) and coffee makes a big difference. If you are consuming these together, there is a good chance you can improve the quality of your cognitive performance and work for longer hours at a time.

Most of the time, people who are using butter coffee find that it is a great way of enjoying coffee, getting replacement calories so they don’t have to eat, and getting a cognitive boost. This is a win-win-win!

Unique blends – there are also unique blends that you can utilize in order to improve the quality of your cognitive performance. Some people stick to Alpha Brain because it is the most popular. There are many well-written Alpha Brain reviews that you can find online, but it is up to you to take everything with a grain of salt as they are trying to sell you something undoubtedly! Keep this in mind whenever you read a review online.

Overall, there are so many different ways that you can improve the quality of your brain, but it is important for you to have the right kind of mentality when you are trying to do things. The vast majority of people who are finding nootropics aren’t interested in following all the latest and greatest information either. If you are video editing, you are more than likely trying to enhance the quality of your work. Any video editor can appreciate better work.

Fasting is the Best Nutritional Supplement

When it comes to improving your life in general terms, you have to do a full analysis and calculation. You may find that some drugs really improve your concentration, but they come with a huge crash and a lot of side effects. Other drugs don’t do much, but they don’t have any side effects either. The best value for your time and energy is a compilation of many different factors and one of those is fasting.

The fasting nutritional supplement is not actually a nutritional supplement at all! It’s just a practice that you can use in order to get a much better experience from your life. Here are a few of the reasons why:

  1. Anti-aging – it is proven that reducing caloric intake has a huge impact on aging. People (and mammals in general) that eat during a smaller period or eat fewer calories will have a much longer lifespan. There is much evidence to suggest that aging is a factor that fasting can negate almost completely. Some studies show a 24% increase in lifespan with fasting (caloric restriction) alone.
  2. Mental performance – after your brain gets used to not using glucose as fuel constantly, it becomes much easier to maintain high mental performance. The vast majority of people who are using markers like mental performance to get ahead at work can find many advantages from this type of thing if they are focusing on the right effects.

Of course, there are plenty of other benefits that you can use to your advantage as well. The vast majority of people who are using the practice find that it is even better when combined with smart drugs and nootropics. One anti-anxiety smart drug called ashwagandha makes a big difference and has a number of profound effects. Even fasting is useful when you have something like adrafinil as the food will not interact negatively with the psychoactive ingredients.

Every Time You Choose This Smart Drug You Get Smarter

There are few nootropic drugs that have the same kind of impact as modafinil (also known as provigil). Even though people find out that the drug is hard to get or it only improves concentration and focus, they also learn that there are plenty of benefits outside of this. Modafinil is a smart drug that isn’t just about getting more focused, but also about improving the quality of that focus and building intelligence over time.

What this looks like in practice is that you can improve your intelligence while studying or doing some kind of work while on the drug. The following article will explain all.

Improving Nootropics Usage

Most people who take this nootropic compound are going to find that it has a number of benefits for studying in the moment. According to the Yerkes-Dodson law, it doesn’t actually make smart people smarter in the moment. However, it can add to general cognition, which has the effect over a course of time. People consistently have to deal with the issue and it is something that nobody likes.

Modafinil allows people to study for a lot longer and a lot more efficiently so that even if they are not going to perform as well on an exam, they can still get the information locked into their head in order to have the best experience. This is one of the best experiences that you can have when it comes to improving your learning ability.

Most people do not consider modafinil for learning enhancement because they are so stuck on whether or not they can improve the level of their memory with such a drug that helps with focus and attention. The vast majority of people who are using these kinds of nootropics figure out that there are other alternatives to modafinil, however. People that don’t want to go against the law find that the adrafinil smart drug called nuvigil is a great option for improving your general cognitive abilities.

3 Differences of Choline to Keep in Mind

When it comes to improving your general cognitive abilities, it is a good idea for you to make sure that you are getting the right kind of supplements. If you have heard of choline as a natural precursor for the neurotransmitter, acetylcholine, then you are already a step ahead of the game. You’ll find that these differences of choline are big and make a difference in your purchasing decisions as well as how your body handles them.

One of the main differences that you should keep in mind with choline is that they are not created equal when it comes to absorption. Some of them are far more useful for your body to absorb than the other types. It is a good idea for you to keep this in mind when you are buying your options.

  1. boiled-eggsPotency – there are many different potency issues when it comes to choline. One of the main choline sources you should use is alpha GPC. This has the most potent version of choline that is well absorbed by your body. It is also going to help you to improve human growth hormone production among other things if that is what you would like! The second most potent is CDP choline, which has other advantages.
  2. Dosage – a lot of choline products require high doses in order to get any kind of benefit. For example the lecithin and choline bitartrate options for choline usually require 5 – 10 times the dosage of the supplement than alpha GPC or CDP choline.
  3. Cost – in addition to the dosage and potency issues that come with choline sources, there is a cost associated with each of these. You’ll find that alpha GPC and CDP choline are more expensive, but they are more potent so you need to take less in order to see profound benefits. This is one of the reason why you need to take cost into account when you are getting choline!

Which Racetam is Right for Me?

Getting started with nootropics can often mean a certain family within the nootropic realm. This family, called racetams, is one of the most well known and studied families that you can possibly find. This is one of the reasons why it is so popular: it is a safe way for people to get experience with nootropics that improve their brain health without having to worry about the safety of their brain and the smart drugs they are taking.

brainThere are plenty of drugs that are experimental and can be dangerous, but racetams are the safest and most well tested. Here is a quick process for you to figure out what racetam might be right for you.

  • Determine your goal – What is your goal from taking nootropics and racetams in particular? If you want to improve your memory formation, then it is a good idea for you to look at piracetam as it is the original racetam, it is the beginner, and it is the one that has the most research for memory formation. However, if you are looking for stimulation, you might want to seek one of the newer options like phenylpiracetam or aniracetam if you don’t want to be too experimental. Finally, there is an analog called oxiracetam that helps you to protect your brain from future damage.
  • Determine your budget – Your budget can also play a role in which racetam is right for you. Even though piracetam is cheap, you have to take a higher dose to see the potency and effects. Other options, like phenylpiracetam, are expensive, but do not require much to see some profound impacts on your mental health.

Once you look at these two things, there is a good chance you will be able to be successful in starting with a new regimen of racetams.

Herbs that Help with Anxiety

For an anxious individual sometimes common meetings or gatherings can be an extremely difficult time. They are often situations that can cause a lot of stress, undue pain, and a lot of added sadness. While there are plenty of methods that one can use in order to help with the anxiety you struggle with, herbal remedies are often the best place to start. Not only are they affordable and easy, but they are also proven over the ages. Here are a few of the best herbal remedies for anxiety:

  • Green tea – the green tea you find in Asia is one of the most relaxing plants you can use because it is filled with an amino acid called L-theanine. This is helpful for removing your anxiety and making you feel better in general
  • Bacopa monnieri – this ancient Indian herb has been used for thousands of years and continues usage today. It is a great way of reducing mental anxiety and stress, which often leads to better performance in mental and cognitive tasks.
  • Lemon balm – another ancient herb, this has been used in the Mediterranean by the Romans and Greek cultures alike. It is a great relaxing and soothing herbal remedy that will help you to feel better and more sedated. It is a great way to relax at the end of the day or just help you to fall asleep easier.
  • AshwagandhaAshwagandha – another Indian herb, this is an option that will help you to reduce your overall stress and it improves your ability to function similar to bacopa monnieri. There is a reason that these awesome ancient herbs have stood the test of time!

All 4 of these are useful therapies for anxiety. If you are struggling with this, you should definitely try them one at a time to see what works best for you.